Though the four factions are distinct in look and team color, there is no difference between each faction in gameplay.

Factions are represented on the scoreboard and in various parts of the HUD by the colors: Blue for Vigilantes, red for Desperados, green for Rangers, and yellow for Banditos. Games may be free-for-all or have up to 4 teams: Desperados, Vigilantes, Rangers, or Banditos. The stars can also be used to spend on perks such as stronger kicks or punches, or being able to carry dynamite or explosive barrels, should you find one. Handedness (left or right) also has significant implications towards accuracy. The player can weigh the star cost of their primary and secondaries to achieve an advantageous loadout. Fistful of Frags also has an intriguing weapons selection system in which stars are used to balance the guns, secondaries, or handedness a player may use. Single-handed weapons may optionally be dual wielded. Many weapons notable for appearing in Wild West media are available, including the Colt Peacemaker, Derringer, and Mare's Leg, Sharps Rifle, and Coachgun. The game supports between 12 and 20 players simultaneously, filling in empty player slots with AI enemies if there are less than 12 players.